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| 慢性阻塞性肺疾病急性加重期痰热证模型大鼠血浆内皮素、降钙素基因相关肽的变化及通塞颗粒的作用 | |
| 引用本文： | 周红艳,乔翠霞,张艳霞,李建生. 慢性阻塞性肺疾病急性加重期痰热证模型大鼠血浆内皮素、降钙素基因相关肽的变化及通塞颗粒的作用[J]. 河南中医学院学报, 2009, 24(5) |
| 作者姓名： | 周红艳 乔翠霞 张艳霞 李建生 |
| 作者单位： | 河南省中医药研究院;河南中医学院老年医学研究所; |
| 基金项目： | 国家自然科学基金(编号:30772797);;河南省高校新世纪优秀人才支持计划(编号:2006HANCET-05) |
| 摘 要： | 目的:探讨慢性阻塞性肺疾病急性加重期(AECOPD)痰热证模型大鼠血浆内皮素(ET)及降钙素基因相关肽(CGRP)的变化及通塞颗粒的作用。方法:通过烟熏、滴菌结合风热刺激的方法建立AECOPD痰热证大鼠模型。采用非平衡法测定血浆ET、CGRP含量。结果:模型组较正常组ET升高(P<0.01),CGRP下降(P<0.05);通塞颗粒组ET较模型组降低(P<0.05),CGRP升高(P<0.05)。结论:ET、CGRP参与了AECOPD的病理生理过程,调节血浆中ET、CGRP的水平可能是通塞颗粒治疗COPD的作用机制之一。 |
| 关 键 词： | 慢性阻塞性肺疾病 急性加重期 痰热证 血浆内皮素 降钙素基因相关肽 通塞颗粒 |
The Change of Calcitonin Gene-Related Peptide and Plasma Endothelin in Rat's Model of Sputum-Pyretic Syndrome in Chronic Obstructive Pulmonary Diseases Acute Exacerbation and Action of Tongsai Granula |
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| Zhou Hongyan,Qiao Cuixia,Zhang Yanxia,Li Jiansheng. The Change of Calcitonin Gene-Related Peptide and Plasma Endothelin in Rat's Model of Sputum-Pyretic Syndrome in Chronic Obstructive Pulmonary Diseases Acute Exacerbation and Action of Tongsai Granula[J]. Journal of Henan University of Chinese Medicine, 2009, 24(5) | |
| Authors: | Zhou Hongyan Qiao Cuixia Zhang Yanxia Li Jiansheng |
| Abstract: | Objective:To approach the change of CGRP and plasma ET in rat's model of sputum-pyretic syndrome in chronic obstructive pulmonary diseases acute exacerbation and action of Tongsai granula. Methods:By smoking and bead bacterium and united wind heat stimulation to setup rat's model of phlegm and pyretic syndrome of AECOPD. Assay content of plasma ET and CGRP with imbalance method. Results:ET in model team is higher than in common team(P<0.01),CGRP in model team is lower(P<0.05),ET in Tongsai granula team is l... |
| Keywords: | chronic obstructive pulmonary diseases acute exacerbation phlegm and pyretic syndrome ET CGRP Tongsai granula |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |