| 斑蝥药材提取工艺及其鼠体刺激性实验 |
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| 引用本文： | 杨薇. 斑蝥药材提取工艺及其鼠体刺激性实验[J]. 抗感染药学, 2011, 8(4): 264-267. DOI: 10.3969/j.issn.1672-7878.2011.04-013 |
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| 作者姓名： | 杨薇 |
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| 作者单位： | 苏州第五人民医院,江苏苏州,215007 |
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| 摘 要： | 目的:建立斑蝥药材提取工艺以及定量测定方法,并考察其对鼠体的刺激性反应。方法:以斑蝥素为指标,采用碱液与乙醇提取法,紫外分光光度法考察斑蝥药材提取液中斑蝥素质量及其对鼠体刺激性反应程度。结果:斑蝥药材提取工艺以75%乙醇液、85℃冷浸提取1h时为最佳提取工艺;其提取物模拟剂型对鼠体的刺激性反应强弱以O/W>W/O或斑蝥药材粉末>脂质体或环糊精。结论:实验建立的斑蝥素含量测定方法适合于斑蝥药材的质量监控,并初步给出了刺激性实验的结果。
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| 关 键 词： | 斑蝥 提取工艺 刺激性 |
Exteaction and Irritant Test of Active Principle of Mylabris in Mouse |
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| YANG Wei. Exteaction and Irritant Test of Active Principle of Mylabris in Mouse[J]. Anti-infection Pharmacy, 2011, 8(4): 264-267. DOI: 10.3969/j.issn.1672-7878.2011.04-013 |
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| Authors: | YANG Wei |
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| Affiliation: | YANG Wei* Suzhou No.5 People's Hospital,Suzhou Jiangsu 215007,China |
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| Abstract: | Objective: To study the optimum extraction process and a method for the quantitative determination of the cantharides herbal medicine and to investigate the thrilling reaction to mice. Method: The cantharidin was detected as indices. By alkali liquor and ethanol extraction process, UV spectrophotometry was used to determine the cantharidin content in the cantharides herbal medicine and the level of thrilling reaction to mice was observed. Results: The optimum extraction process was as follows: the concentra... |
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| Keywords: | Cantharidin extractionprocess irritation |
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