Lung density distribution in dynamic CT correlates with oxygenation in ventilated pigs with lavage ARDS |
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| Authors: | Markstaller K Kauczor H-U Weiler N Karmrodt J Doebrich M Ferrante M Thelen M Eberle B |
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| Affiliation: | Departments of 1 Anaesthesiology and 2 Radiology, Johannes Gutenberg-University, School of Medicine, Langenbeckstrasse 1, D-55131 Mainz, Germany. 3 Department of Anesthesia, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA 4 Present address: Veteran’s Administration Medical Center, Los Angeles, University of California, 11301 Wilshire Boulevard, Los Angeles, CA 90070, USA |
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| Abstract: | ![]()
Background. Fast dynamic computed tomography (dCT) has beenused to assess regional dynamics of lung inflation and deflationprocesses. The aim of this study was to relate ventilation-inducedchanges in lung density distribution, as measured over severalrespiratory cycles by dCT, to oxygenation and shunt fractionin a lavage acute respiratory distress syndrome model. Methods. Six anaesthetized pigs underwent pressure-constantventilation (FIO2=1.0, inspiratory:expiratory ratio=1:1) beforeand after induction of lung damage by saline lavage. Mean airwaypressure (P |
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| Keywords: | complications, acute respiratory distress syndrome lung, lavage lung, respirator therapy measurement techniques, dynamic computed tomography pig |
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