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Protective effects of curcumin against human immunodeficiency virus 1 gp120 V3 loop-induced neuronal injury in rats |
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| Authors: | Zheng Gong Lijuan Yang Hongmei Tang Rui Pan Sai Xie Luyan Guo Junbin Wang Qinyin Deng Guoyin Xiong Yanyan Xing Jun Dong |
| Affiliation: | 1, 2, 3 1Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China 2Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China 3Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzhou 510632, Guangdong Province, China 4Department of Orthopedics, First Affiliated Hospital, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China |
| Abstract: | Curcumin improves the learning and memory deficits in rats induced by the gp120 V3 loop. The present study cultured rat hippocampal neurons with 1 nM gp120 V3 loop and 1 μM curcumin for 24 hours. The results showed that curcumin inhibited the gp120 V3 loop-induced mitochondrial membrane potential decrease, reduced the mRNA expression of the pro-apoptotic gene caspase-3, and attenuated hippocampal neuronal injury. |
| Keywords: | curcumin gp120 V3 loop hippocampal neurons mitochondrial membrane potential caspase-3 human immunodeficiency virus-associated neurocognitive function neural regeneration |
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