| Abstract: | ![]()
The effect of haloperidol on convulsions induced in mice by bicuculline and thiosemicarbazide and on recovery cycles of the primary sensomotor cortical response in rats was studied. In a dose of 0.3–0.5 mg/kg, giving a tranquilizing effect, haloperidol had a protective action against convulsions induced by blockade of GABA receptors through the action of bicuculline, and potentiated depression of the testing response in the recovery cycle of the primary sensomotor cortical response in rats, i. e., within this dose range haloperidol potentiates GABA effects. With an increase in the dose of haloperidol to 1–2 mg/kg its effectiveness in both tests disappeared. On the basis of these results and data in the literature it is suggested that the postsynaptic GABA-positive effect plays an important role in the mechanism of the tranquilizing action of haloperidol and of other neurotropic agents.Laboratory of Pharmacology of the Nervous System, Institute of Pharmacology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR V. V. Zakusov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 89, No. 3, pp. 313–315, March, 1980. |
