Protocols for the use of cyproterone, medroxyprogesterone, and leuprolide in the treatment of paraphilia.

OBJECTIVE: To propose a protocol for minimizing medical complications associated with the use of cyproterone, medroxyprogesterone, and depot leuprolide to treat paraphilia. METHOD: Review of the relevant literature. RESULTS: Certain patient populations should not be treated with these medications, and medical complications associated with each can be detected early and avoided. CONCLUSIONS: For each drug, a series of screening tests prior to use and scheduled testing during use can minimize potential medical complications.