人型支原体合并解脲脲原体感染的检出率和耐药性分析

目的了解泌尿生殖道人型支原体（Mycoplasma hominis，Mh）单纯及合并解脲脲原体（Ureaplasma urealyticum，Uu）的感染和耐药情况。方法用选择性固体培养基-液体培养基一步法检测7486例生殖泌尿道标本中Mh的检出率和耐药情况。结果Mh单纯检出率为2．8％，合并Uu检出率为11．3％，女性检出率高于男性（P〈0．05）。Mh和Mh合并Uu对多西环素和米诺环素的敏感率最高，均〉90．0％，对红霉素、罗红霉素、阿奇霉素和克拉霉素耐药率最高，耐药率均大于90，0％。两者对这6种抗生素的敏感率和耐药率差异无统计学意义（P〉0．05）。Mh对交沙霉素的敏感率（87．6％）高于混合感染者（75．4％），差异有统计学意义（P〈0．05）。结论Mh单纯感染或混合感染检出率较低，且以女性感染为主，两者的耐药谱基本一致，对半合成四环素的敏感率最高，对大环内酯类抗生素耐药率最高。

Prevalence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma ureal yticum coinfection

Objective To compare the prevalence and antibiotic susceptibility of Mycoplasma hominis （Mh） monoinfection and coinfection with Ureaplasrna urealytiurn （Uu）. Methods A total of 7 486 samples were collected from urogenital tract and cul-tured in the liquid culture medium and selective solid culture medium concomitantly. The prevalence and antibiotic susceptibility were compared and analyzed. Results The prevalence of Mh monoinfection and Mh ＋ Uu coinfection was 2.8 % and 11.3%, respectively. The prevalence was significantly higher in female patients than in male patients （P〈0.05）. More than 90.0% of the isolates from either Mh monoinfection or Mh ＋ Uu coinfection were sensitive to doxycycline and minocycline. However, more than 90.0% of the isolates were resistant to erythromycin, roxithromycin, azithromycin or clarithromycin. No significant difference was found between Mh and Mh ＋ Uu in the in vitro susceptibility to the six antibiotics （P〉0.05）. The susceptibility to josamycin was significantly different between Mh and Mh ＋ Uu （87.60% vs. 75.4%, P〈0.05）. Conclusions The prevalence of Mh and Mh ＋ Uu is tow in genitourinary tract infections. Mh and Mh ＋ Uu infections are mainly found in females. Both Mh and Mh ＋ Uu show similar antibiotic resistant pattern, which indicates good susceptibility to semisynthetic tetracyclines and high resistance to macrolides.