| 酒肝清胶囊中甘草酸的溶出度测定 |
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| 引用本文： | 李海燕,金向群,随志刚,孙明谦,代春红,肖锋,睢诚.酒肝清胶囊中甘草酸的溶出度测定[J].中国实验方剂学杂志,2008,14(4):6-8. |
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| 作者姓名： | 李海燕 金向群 随志刚 孙明谦 代春红 肖锋 睢诚 |
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| 作者单位： | 1. 吉林大学药学院,吉林,长春,130021
2. 中国药科大学,江苏,南京,210009 |
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| 基金项目： | 吉林省科委项目(20050910) |
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| 摘 要： | 目的对酒肝清胶囊中甘草酸进行了溶出度测定,以考察其内在质量.方法应用搅拌浆法,以HPLC法测定酒肝清胶囊中甘草酸的含量为指标,对酒肝清胶囊中甘草酸进行溶出度测定.结果以含0.5%十二烷基硫酸钠的蒸馏水溶液为溶剂,转速100 r·min,经45 min,溶出度为标示量的75%以上.结论溶出度测定是控制中药复方制剂内在质量的一种可行的方法.
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| 关 键 词： | 酒肝清 甘草酸 溶出度 高效液相色谱法 |
| 文章编号： | 1005-9903(2008)04-0006-03 |
| 收稿时间： | 8/9/2007 12:00:00 AM |
| 修稿时间： | 2007年8月9日 |
Study on Dissolution of Glycyrrhizic Aeid in Jiuganqing Capsules |
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| LI Hai-yan,JIN Xiang-qun,SUI Zhi-gang,SUN Ming-qian,DAI Chun-hong,XIAO Feng,SUI Cheng.Study on Dissolution of Glycyrrhizic Aeid in Jiuganqing Capsules[J].China Journal of Experimental Traditional Medical Formulae,2008,14(4):6-8. |
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| Authors: | LI Hai-yan JIN Xiang-qun SUI Zhi-gang SUN Ming-qian DAI Chun-hong XIAO Feng SUI Cheng |
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| Institution: | 1.School of Pharmacy of Jilin University,Changchun 130021,China;2.China Pharmaceutical University,Nanjing 210009,China |
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| Abstract: | Objective:To determine the dissolutions of glycyrrhizic acid in Jiuganqing capsules in order to examine its inner qualitiy.Method:The content of glycyrrhizic acid was determined by HPLC as index to determine the dissolution of glycyrrhizic acid in Jiuganqing capsules by paddle method.Result:900 mL of 0.5% SDS solution was used as solvent.Paddle method was used with rotation rate at 100 r.min-1,after 45 min,dissolution is over 75% labelled amount.Conclusion: The determination of dissolution is a feasible method for controlling the inner quality of traditional Chinese medicinal preparations. |
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| Keywords: | Jiuganqing capsules glycyrrhizic acid dissolution HPLC |
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