| 脂肪组织甘油三酯脂肪酶的研究进展 |
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| 引用本文： | 洪燕青,邸阜生.脂肪组织甘油三酯脂肪酶的研究进展[J].国际内分泌代谢杂志,2010,30(2). |
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| 作者姓名： | 洪燕青 邸阜生 |
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| 作者单位： | 1. 天津医科大学研究生院,300070
2. 天津市第三中心医院内分泌科,300170 |
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| 摘 要： | 脂肪组织甘油三酯脂肪酶(ATGL)是新近发现的启动脂肪动员的另一关键酶,其主要催化脂肪组织中甘油三酯生成甘油二酯,与长期认为的经典限速酶激素敏感性脂肪酶(HSL)在脂肪分解途径中共同承担着重要作用.鉴于ATGL与脂肪分解密切相关,并在脂肪代谢紊乱性疾病中发挥着重要的作用,本文就ATGL的研究进展及与脂肪分解、肥胖和2型糖尿病等脂代谢紊乱性疾病的关系作一综述.
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| 关 键 词： | 脂肪组织甘油三酯脂肪酶 激素敏感性脂肪酶 脂肪分解 肥胖 2型糖尿病 |
Recent progress in adipose triglyceride lipase |
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| HONG Yan-qing,DI Fu-sheng.Recent progress in adipose triglyceride lipase[J].International JOurnal of Endocrinology and Metabolism,2010,30(2). |
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| Authors: | HONG Yan-qing DI Fu-sheng |
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| Abstract: | Adipose triglyceride lipase (ATGL) is a newly discovered key enzyme that initiates fat mobilization and predominantly hydrolyzes triglyceride into diglyeeride.It plays a pivotal role during lipolysis with hormone sensitive lipase(HSL) that was recognized as the typical rate-limiting enzyme.ATGL is related to lipolysis, and plays an importart role in dyslipidemia and related disease.This review focuses on ATGL and its relation with lipolysis,obesity,typo 2 diabetes mellitus. |
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| Keywords: | Adipose triglyceride lipase Hormone sensitive lipase Lipolysis Obesity Type 2 dia-betes mellitus |
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