Cytotoxic macrolides from a cultured marine dinoflagellate of the genus Amphidinium |
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| Authors: | J Kobayashi M Ishibashi H Nakamura Y Ohizumi T Yamasu Y Hirata T Sasaki T Ohta S Nozoe |
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| Affiliation: | Mitsubishi Kasei Institute of Life Sciences, Minamiooya, Machida, Tokyo, Japan. |
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| Abstract: | ![]()
A fourth cytotoxic macrolide, amphidinolide D[1], together with known amphidinolide B[2], has been isolated from a different batch of the cultured dinoflagellate Amphidinium sp., which was symbiotically associated with an Okinawan flatworm Amphiscolops sp. Two-dimensional nmr experiments including 1H-detected heteronuclear multiple-bond correlation (HMBC) resulted in the structure assignment of 1 and structure revision of the diene moiety (C-13-C-15) of amphidinolide B. |
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