| SELDI-TOF-MS在筛选结直肠癌相关生物标记物中的应用 |
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| 引用本文： | 张扬,李志霞.SELDI-TOF-MS在筛选结直肠癌相关生物标记物中的应用[J].国际外科学杂志,2008,35(11):757-760. |
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| 作者姓名： | 张扬 李志霞 |
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| 作者单位： | 首都医科大学附属北京同仁医院普外科,北京,100730 |
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| 摘 要： | 表面增强激光解吸/电离-飞行时间-质谱(surface-enhanced laser desorption/ionizationtime of flight-mass spectrometry,SELDI-TOF-MS)是一项新的蛋白质组学技术,近年来运用该技术发现了一些能用于结直肠癌早期诊断、术前分期或预测放化疗疗效的新的牛物标记物,其敏感性和特异性均高于传统的生物标记物.SELDI-TOF-MS可能会对结直肠癌的早期诊断和个体化治疗带来帮助.
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| 关 键 词： | 表面增强激光解吸/电离-行时间-质谱 结直肠癌 生物标记物 |
Application of SELDI-TOF-MS in searching for biomarkers for colorectal cancer |
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| ZHANG Yang,LI Zhi-Xia.Application of SELDI-TOF-MS in searching for biomarkers for colorectal cancer[J].International Journal of Surgery,2008,35(11):757-760. |
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| Authors: | ZHANG Yang LI Zhi-Xia |
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| Abstract: | SELDI-TOF-MS is a novel proteomic technique.It reveals some new biomarkers which could be used for early diagnosis,preoperative staging and predicting response to radiochemotherapy of colorectal cancer.These new biomarkers were validated to be more sensitive and specific than traditional hiomarkers.SELDI-TOF-MS will be a useful tool for early diagnosis and tailor-made therapy of eolorectal cancer. |
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| Keywords: | SELDI-TOF-MS coloreetal cancer biomarker |
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