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| 5羟色胺1B受体在小鼠耳蜗螺旋神经元上的表达及意义 | |
| 引用本文： | 白云丹,喻超,唐玥玓. 5羟色胺1B受体在小鼠耳蜗螺旋神经元上的表达及意义[J]. 西部医学, 2012, 24(6): 1056-1058 |
| 作者姓名： | 白云丹 喻超 唐玥玓 |
| 作者单位： | 四川大学华西医院耳鼻咽喉头颈外科,四川成都,610041 |
| 基金项目： | 由国家自然科学基金课题 |
| 摘 要： | 目的研究小鼠耳蜗螺旋神经元上5羟色胺（serotonin，5-HT）1B受体的表达并探讨其意义。方法采用成熟昆明小鼠耳蜗石蜡切片，运用免疫组化技术检测耳蜗螺旋神经元上5羟色胺1B受体的表达。结果实验组小鼠耳蜗螺旋神经元胞浆内显示阳性表达信号，阴性对照组未发现阳性信号。结论5羟色胺1B受体存在于听觉传导通路的第一级神经元，支持5羟色胺作为其递质，对神经兴奋性起着重要的调节作用。 |
| 关 键 词： | 螺旋神经元 5羟色胺 受体 神经递质 免疫组化技术 |
Localization and significance of serotonin receptor 1B in the spiral ganglion in micee |
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| BAI Yun-dan , YU Chao , TANG Yue-di. Localization and significance of serotonin receptor 1B in the spiral ganglion in micee[J]. , 2012, 24(6): 1056-1058 | |
| Authors: | BAI Yun-dan YU Chao TANG Yue-di |
| Affiliation: | BAI Yun-dan,YU Chao,TANG Yue-di(Department of Otalaryngology-Head and Neck Surgery,West China Hospital,Sichuan University,Chengdu 610041,China) |
| Abstract: | ObjectiveTo investigate the expression of serotonin(5-HT) receptor 1B in spiral ganglion and its’ significance.MethodsIn the cochlear paraffin slides,The immunohistochemistry technique was used to locate serotonin receptor 1B in the spiral ganglion.ResultsApositive signal was showed in the experimental group,as a negative signal was showed in the control group without serotonin receptor 1B antibody.ConclusionThe results demonstrate that the spiral ganglion neurons contain serotonin receptor 1B.It strongly indicates that serotonin as a neurotransmitter plays an important role in regulating neural activity. |
| Keywords: | Spiral ganglion neuron Serotonin Receptor Neurotransmitter Immunohistochemistry technique |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |