睡眠剥夺后类比推理认知功能改变的功能性磁共振成像个体差异初步分析(英文)

目的研究睡眠剥夺后类比推理认知功能改变在功能性磁共振成像上的个体差异表现。方法对30例健康志愿者(男性18例,女性12例,平均年龄40岁)进行2次类比推理功能磁共振成像扫描,分别于正常睡眠情况下和睡眠剥夺24小时后,扫描顺序是制衡的。扫描后根据参与者的行为学表现(反应时间与错误率)分别将其分成睡眠剥夺易损组及睡眠剥夺拮抗组,再回顾分析功能性磁共振成像上个体差异表现。数据处理由统计参数图及功能性神经影像分析软件完成。结果正常睡眠情况下,睡眠剥夺易损组的脑活动较睡眠剥夺拮抗组明显减少;睡眠剥夺后,易损组的脑活动显著减少,而睡眠剥夺拮抗组脑活动显著增加。结论不同人群对睡眠剥夺后的人脑反应不尽相同;磁共振成像可能成为睡眠剥夺易损性的一种预测手段。

Individual differences in cortical response to analogy following 24 hours of sleep deprivation

Objective To investigate individual differences in cerebral hemodynamic response to analogy following sleep deprivation(SD).Methods 30 subjects were scanned twice with functional magnetic resonance imaging(fMRI) at a counter-balanced order after a normal night of sleep(rested state),and 24 hours of SD state.Subjects performed analogy tasks alternated with a control tasks during the fMRI scan that lasted 12 minutes and 48 seconds.Based on individual behavioral performance after SD,subjects were separated into two subgroups—SD vulnerable(SDV) and SD resilient(SDR) groups.Subgroup data were reanalyzed with Statistical Parametric Mapping(SPM) and Analysis of Functional NeuroImages(AFNI).Results At the rested baseline,the brain activation induced by analogy in the SDR group was more than that in the SDV group.After SD,the brain became less responsive in the SDV group but more active in the SDR group,although similar patterns of brain activation were observed in both the rested and SD states.Conclusion Individuals respond to SD differently,fMRI at normal sleep baseline may be useful in predicting the vulnerability of SD.