青岛地区男性不育症患者1124例细胞遗传学分析

目的探讨男性不育症与异常染色体核型的关系。方法采用常规G显带方法对1124例不育男性患者行细胞遗传学检查。结果检出异常核型121例,异常检出率10.77%。其中Klinefelter＇s syndrome 49例,占异常核型40.5%;Y染色体形态异常35例,占异常核型28.9%;染色体多态性变化14例,占异常核型11.6%;染色体臂间或臂内倒位携带者2例,占异常核型1.7%;平衡易位携带者17例,占异常核型14.0%;染色体嵌合体4例,占异常核型3.3%。结论染色体核型异常是男性不育症的主要原因之一,对男性不育症患者进行细胞遗传学分析,可为临床诊断和治疗提供科学依据。

Cytogenetis analysis on 1124 cases of male infertility

Objective:To study the relationship between male infertility and abnormal chromosome karyotypes.Methods: Giemsa banding chromosome analysis was done in 1124 cases of male infertility for routine cytogenetic analysis.Results:There were 121 cases of abnormal karyotypes which is 10.77% in all examiners.They included 49 cases of Klinefelter′s syndrome which was 40.5% in all abnormal karyotypes;There were 35 cases of Y chromosome abnormal morphology which were 28.9% in chromosome abnormalities;They included 14 cases of chromosome polymorphism changes which were 11.6% in all abnormal karyotypes.There were 2 cases with chromosome inversion which were 1.7% in all abnormal karyotypes;17 cases with balanced translocation were checked out,which were 14.0% in chromosome abnormalities;There were 4 cases of chromosome chimeare which were 3.3% in all abnormal karyotypes.Conclusion: The abnormality of chromosome karyotype should be one of the basic reasons of male infertility.Cytogenetics analysis to male infertility can provide aids on the diagnosis and treatment of infertility couples.