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| 尿苷二磷酸葡醛酸转移酶的代谢类型及影响因素 | |
| 引用本文： | 郑水莲,李新,曾苏. 尿苷二磷酸葡醛酸转移酶的代谢类型及影响因素[J]. 中国药理学与毒理学杂志, 2005, 19(1): 75-80 |
| 作者姓名： | 郑水莲 李新 曾苏 |
| 作者单位： | 浙江大学药学院,浙江,杭州,310031 |
| 基金项目： | 国家自然科学基金，国家自然科学基金，浙江省自然科学基金 |
| 摘 要： | 尿苷二磷酸葡醛酸转移酶 (UGT)是一类Ⅱ相代谢酶 ,能催化葡醛酸与其相应底物结合。该过程是机体的重要排泄途径之一。目前 ,有 15种人类UGT被确证有活性 ,而且对它们的底物选择性方面有了进一步认识 ,但UGT的酶学研究相对于细胞色素P4 5 0还比较落后 ,有待于进一步提高。 |
| 关 键 词： | 尿苷二磷酸葡醛酸转移酶 葡醛酸结合反应 |
| 收稿时间： | 2003-12-19 |
Uridine 5-diphosphate glucuronosyltransferases involved metabolism types and factors influencing glucuronidation |
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| ZHENG Shui-Lian,LI Xin,ZENG Su. Uridine 5-diphosphate glucuronosyltransferases involved metabolism types and factors influencing glucuronidation[J]. Chinese Journal of Pharmacology and Toxicology, 2005, 19(1): 75-80 | |
| Authors: | ZHENG Shui-Lian LI Xin ZENG Su |
| Affiliation: | (College of Pharmaceutical Sciences,Zhejiang University, Hangzhou 310031, China) |
| Abstract: | Uridine 5-diphosphate glucuronosyltransferas es (UGT) are a superfamily of phase Ⅱ-enzymes which can catalyze the conjugat ion of glucuronic acid to substrates. This is one of the important mechanisms of drug elimination. At present, about 15 human UGT have been identified, and muc h more knowledge about substrate selectivity of UGT has been reported. However, the study on enzymology of UGT lags behind that of cytochrome P450. |
| Keywords: | uridine 5-diphosphate glucuronosyltransferases glucuron idation |
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