阿尔采末病发病机制与表观遗传学研究进展

简要介绍AD神经化学改变的机制、表观遗传学与基因表达的调节和表观遗传学机制在SAD(sporadic Alzheimer′s disease,SAD)中的作用结果。近几十年来对AD的基础研究进展,初步揭开了AD深不可测的神经化学改变的谜团,尤其是近些年将SAD复杂的蛋白质表达异常定位在表观遗传学疾病,使AD的发病原因、机制和防治提出了新的策略性方向,随着对表观遗传学生物特性的理解,AD更值得深入的研究。

Alzheimer's disease pathogenesis and apparent progress in genetic research

This paper briefly describes the mechanism of neurochemical changes in AD,the roles of the epigenetics,the regulation of gene expression and the mechanism of epigenetics in SAD.On the basis of the basic study on the AD during the decades,researchers initially revealed the mystery of the unfathomable neurochemical changes attack on AD.Especially in recentyears,researchers summarized the abnormal protein expression on SAD into epigenetics disease.This achievement helps researchers point out the new and strategic direction on AD pathogenesis,prevention and control mechanism.With the understanding of biological characteristics of epigenetics,AD needs to be studied in depth.