Development of high refractive ZnS/PVP/PDMAA hydrogel nanocomposites for artificial cornea implants |
| |
| Institution: | 1. Institute of Pharmaceutical Science, Faculty of Life Sciences and Medicine, King''s College, LondonUK;2. MRC-PHE Centre for Environment and Health and NIHR-HPRU in the Health Impact of Environmental Hazards, Environmental and Analytical Research, Division, Faculty of Life Sciences and Medicine, King''s College, London, UK;3. MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, Faculty of Life Sciences and Medicine, King''s College, London, UK;4. Centre for BioNano Interactions, University College Dublin, Belfield, Dublin 4, Ireland;5. Department of Chemistry – BMC, Uppsala University, Sweden;6. Institute of Psychiatry, Psychology and Neuroscience, Faculty of Life Sciences and Medicine, King''s College, London, UK;7. Genomics Centre, Faculty of Life Sciences and Medicine, King''s College, London, UK;8. Department of Public Health and Clinical Medicine, Division of Medicine/Respiratory Medicine and Allergy, Umeå University, Umeå, Sweden;9. GSK Medicines Research Centre, Stevenage, Hertfordshire, UK |
| |
| Abstract: | A series of high refractive index (RI) ZnS/PVP/PDMAA hydrogel nanocomposites containing ZnS nanoparticles (NPs) were successfully synthesized via a simple ultraviolet-light-initiated free radical co-polymerization method. The average diameter of the ZnS NPs is ～3 nm and the NPs are well dispersed and stabilized in the PVP/PDMAA hydrogel matrix up to a high content of 60 wt.% in the hydrogel nanocomposites. The equilibrium water content of ZnS/PVP/PDMAA hydrogel nanocomposites varied from 82.0 to 66.8 wt.%, while the content of mercaptoethanol-capped ZnS NPs correspondingly varied from 30 to 60 wt.%. The resulting nanocomposites are clear and transparent and their RIs were measured to be as high as 1.58–1.70 and 1.38–1.46 in the dry and hydrated states, respectively, which can be tuned by varying the ZnS NPs content. In vitro cytotoxicity assays suggested that the introduction of ZnS NPs added little cytotoxicity to the PVP/PDMAA hydrogel and all the hydrogel nanocomposites exhibited minimal cytotoxicity towards common cells. The hydrogel nanocomposites implanted in rabbit eyes can be well tolerated over 3 weeks. Hence, the high RI ZnS/PVP/PDMAA hydrogel nanocomposites with adjustable RIs developed in this work might potentially be a candidate material for artificial corneal implants. |
| |
| Keywords: | Polymers Hydrogel ZnS nanoparticles Refractive indices Cornea implants |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
