Age-dependent suppression of hippocampal epileptic afterdischarges by metabotropic glutamate receptor 5 antagonist MTEP |
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| Affiliation: | 2. Laboratorio de Nanotecnología, Instituto Nacional de Neurología y Neurocirugía-MVS, Mexico D.F., Mexico;3. Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados Sede Sur, Mexico D.F., Mexico;4. Departamento de Biofísica, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico D.F., Mexico;1. Department of Life and Environment Sciences, Section of Neuroscience, University of Cagliari, Cagliari, Italy;2. Department of Psychology and Neuroscience Program, University of Guelph, Guelph, ON, Canada;3. Institute of Neuroscience, National Research Council of Italy (CNR), Cagliari, Italy |
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| Abstract: | Action of an antagonist of metabotropic glutamate receptors subtype 5 MTEP was studied in a model of complex partial seizures. Dorsal hippocampus of rat pups 12, 18 and 25 days old was stimulated six times with 10-min intervals. MTEP (20 or 40 mg/kg) was injected after the first afterdischarge and duration of afterdischarges was measured.MTEP exhibited marked anticonvulsant action in 12-day-old-rats, the similar effect in 18-day-old rats was observed only with the second stimulation. No anticonvulsant action was seen in 25-day-old animals.Our results may qualify antagonists of mGluR5 as potential antiepileptic drugs for some types of childhood epilepsies. |
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| Keywords: | Epileptic afterdischarge Hippocampus Rat Ontogeny Metabotropic glutamate receptor 5 |
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