Heparin-functionalized polymeric biomaterials in tissue engineering and drug delivery applications |
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| Institution: | 1. Department of Materials Science and Engineering, 201 DuPont Hall, University of Delaware, Newark, DE 19716, USA;2. Biomedical Engineering, University of Delaware, Newark, DE 19716, USA;3. Delaware Biotechnology Institute, 15 Innovation Way, University of Delaware, Newark, DE 19711, USA;1. Tufts University, Department of Biomedical Engineering, 4 Colby Street, Medford, MA 02155, USA;2. Leibniz Institute of Polymer Research Dresden, Max Bergmann Centre for Biomaterials Dresden, Hohe Str. 6, Dresden 01069, Germany;3. Center for Regenerative Therapies, Dresden University of Technology, Fetscherstraße 105, Dresden 01307, Germany;4. Department of Chemical and Biological Engineering, 4 Colby Street, Medford, MA 02155, USA;1. The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, 315 Ferst Drive, Atlanta, GA 30332, USA;2. The Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA 30332, USA;3. The George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 801 Ferst Drive, Atlanta, GA 30332, USA;1. Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603203, Tamil Nadu, India;2. Department of Chemical Engineering, Ming Chi University of Technology, Taishan, Taipei 24301, Taiwan;1. Key Laboratory of Advanced Technology of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, People’s Republic of China;2. Naton Medical Group, Peking 100082, People’s Republic of China;3. Leibniz Institute of Polymer Research Dresden, Max Bergmann Center of Biomaterials, Hohe Str. 06, 01069 Dresden, Germany;1. Department of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences and Networking Biomedical Research Centre on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), University of Alcalá, Alcalá de Henares, Madrid, Spain;2. Department of Biomedical Sciences (Pharmacology), Faculty of Medicine and Health Sciences, University of Alcalá, Madrid, Spain;3. Ramón y Cajal Institute of Healthcare Research (IRYCIS), Madrid, Spain;4. Department of Surgery, Medical and Social Sciences, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain;5. Institute of Polymer Science and Technology, ICTP-CSIC, Madrid, Spain;6. Immune System Diseases-Rheumatology, Oncology and Internal Medicine Service, CIBEREHD, University Hospital Príncipe de Asturias, Alcalá de Henares, Madrid, Spain |
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| Abstract: | Heparin plays an important role in many biological processes via its interaction with various proteins, and hydrogels and nanoparticles comprising heparin exhibit attractive properties, such as anticoagulant activity, growth factor binding, and antiangiogenic and apoptotic effects, making them great candidates for emerging applications. Accordingly, this review summarizes recent efforts in the preparation of heparin-based hydrogels and formation of nanoparticles, as well as the characterization of their properties and applications. The challenges and future perspectives for heparin-based materials are also discussed. Prospects are promising for heparin-containing polymeric biomaterials in diverse applications ranging from cell carriers for promoting cell differentiation to nanoparticle therapeutics for cancer treatment. |
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| Keywords: | Heparin Hydrogels Nanoparticles Tissue engineering Drug delivery |
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