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Non-pulmonary involvement in COVID-19: A systemic disease rather than a pure respiratory infection
Authors:Mohamed El-Kassas  Mohamed Alboraie  Mohamed Elbadry  Reem El Sheemy  Mohamed Abdellah  Shimaa Afify  Ahmad Madkour  Mariam Zaghloul  Abeer Awad  Mohamed-Naguib Wifi  Amira Al Balakosy  Mohamed Eltabbakh
Abstract:During the early phase of the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), diagnosis was difficult due to the diversity in symptoms and imaging findings and the variability of disease presentation. Pulmonary manifestations are reportedly the main clinical presentations of COVID-19 patients. Scientists are working hard on a myriad of clinical, epidemiological, and biological aspects to better understand SARS-CoV-2 infection, aiming to mitigate the ongoing disaster. Many reports have documented the involvement of various body systems and organs apart from the respiratory tract including the gastrointestinal, liver, immune system, renal, and neurological systems. Such involvement will result in diverse presentations related to effects on these systems. Other presentations such as coagulation defects and cutaneous manifestation may also occur. Patients with specific comorbidities including obesity, diabetes, and hypertension have increased morbidity and mortality risks with COVID-19.
Keywords:COVID-19  Non-pulmonary  Extrapulmonary  Clinical manifestations  Systemic disease
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