复方冬元膏戒毒效应的实验研究

本研究观察中药制剂复方冬元膏对动物药物依赖性的影响。用逐次逐日增加吗啡注射剂量的方法造成大鼠及小鼠的吗啡依赖性模型后,又分别为中药大、小剂量组,吗啡维持组,空白对照组;再给予腹腔注射纳洛酮催瘾,观察经不同药物处理后动物的戒断症状反应。结果表明：中药能明显抑制成瘾大鼠的戒断症状及成瘾小鼠的跳跃反应。

Experimental Study on the Effect of Abstinence with Herbal Preparation Composite Dong Yuan Gao

The effect of herbal preparation"Composite Dong Yuan Gao" (CDYG)on the animal model of drug dependence was studied.After the morphinistic models of white rats and mice were made by ever increasing doses of morphine each time,the animals were divided into large dose CDYG group,small dose CDYG group, sustained morphine group,and control group.The withdrawal symptoms were observed after naloxone was given to the animals intraperitoneally.The results showed that in the CDYG groups withdrawal symptoms of the addicted white rats were alleviated,the number of jumps of the addicted mice was reduced, the scores of the principal symptoms of the animals were decreased,while the body weights of the animals were gained.Comparing with the control group,the difference was significant(P<0.01).The effects of the CDYG enhanced in the large dose group,which suggests that the CDYG has abstinence effects.