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| 5-(2-羟乙基)-4-甲基-恶唑的合成及其光谱研究 | |
| 引用本文： | 田世雄,Matlin SA. 5-(2-羟乙基)-4-甲基-恶唑的合成及其光谱研究[J]. 华中科技大学学报(医学版), 1986, 0(3) |
| 作者姓名： | 田世雄 Matlin SA |
| 作者单位： | 同济医科大学药学系有机化学教研室(田世雄)，英国城市大学化学系(Matlin SA) |
| 摘 要： | 本文叙述了5-(2- 羟乙基)-4-甲基-恶唑的合成及其反应机理。用3-氯-5-羟基-2-戊酮与甲酰胺为原料经环合、水解反应得到了所需要的产品,对中间体及产品进行的光谱研究,证明了1966年Lindberg UH得到的产物为酯,而不是原料甲酸胺与产品醇的混合物。 |
| 关 键 词： | 5-(2-羟乙基)-4-甲基-恶唑 环合 5-(2-氯乙基)-4-甲基-恶唑 羟乙基 焦磷酸 5-(2-羟乙基)-4-甲基-恶唑甲酸酯 咪唑 |
Synthesis of 5-(2-Hydroxyethyl)-4-Methyl-Oxazole and Study of its Spectra |
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| Tian Shixiong. Synthesis of 5-(2-Hydroxyethyl)-4-Methyl-Oxazole and Study of its Spectra[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 1986, 0(3) | |
| Authors: | Tian Shixiong |
| Affiliation: | Tian ShixiongDepartment of Organic Chemistry,Pharmacy Faculty,Tongji Medical University,WuhanDr Matlin SA Department of Chemistry. City University,United Kingdom |
| Abstract: | The ester of the title compound is obtained directly by the cyclization of the halo-ketone containing side chain and formamide,The product obtained by hydrolysis of ester is really 5-(-hydroxyethyl)-4-methyl-oxazole.The analysis of the spectra from ester and alcohol has proved that the product collected by Ulf Henrik Lindberg is not a mixture of alcohol and formamide but,an ester.The mechanism of the cyclization has been evaluated. |
| Keywords: | 5-(2-hydroxyethyl)-4-methyl-oxazole cyclization 5-(2-chloroe-thyl)-4-methyl-oxazole hydroxyethyl polyphosphoric acid 5-carbethoxy-4-me-thyl-oxazole imidazole |
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