| 超声波介导的基因输送技术 |
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| 引用本文： | 何伟,刘睿,陈亚珠,徐宇虹.超声波介导的基因输送技术[J].生物医学工程学杂志,2005,22(2):403-406. |
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| 作者姓名： | 何伟 刘睿 陈亚珠 徐宇虹 |
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| 作者单位： | 1. 上海交通大学,生命科学技术学院,上海,200030
2. 上海交通大学,药学院,上海,200030 |
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| 摘 要： | 近年来超声波介导的基因输送技术由于其相对安全性和操作上的简单得到关注。本文对超声波导致的声致穿孔的机制,空化核的作用——增强基因输送的效率,以及细胞和在体基因输送效率作了综述,讨论了超声波介导的基因输送效率的影响因素。此方法充满希望并且载药的空泡可以作为一种新型药物载体在超声作用下实现药物的靶向输送
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| 关 键 词： | 基因输送 超声波 声致穿孔 造影剂 |
| 收稿时间： | 2002-11-29 |
| 修稿时间： | 2002-11-292003-02-25 |
Ultrasound-mediated Gene Delivery |
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| He Wei,Liu Rui,Chen Yazhu,Xu Yuhong.Ultrasound-mediated Gene Delivery[J].Journal of Biomedical Engineering,2005,22(2):403-406. |
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| Authors: | He Wei Liu Rui Chen Yazhu Xu Yuhong |
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| Institution: | 1 College of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai 200030,China;2 School of Pharmacy, Shanghai Jiaotong University, Shanghai 200030,China |
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| Abstract: | Recently there have been increasing interests in ultrasoun d-mediated ge ne delivery techniques. This paper reviews the general concept of sonoporation, the effect of contrast agents, and the in vitro and in vivo applications of such techniques. Factors which contribute to the efficiency of gene delivery were al so discussed. The technology is promising and has great potential in targeted dr ug delivery and gene delivery applications. |
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| Keywords: | Gene delivery Ultrasound Sonoporation Contrast agent |
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