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Immunohistochemical analysis of centromere protein F expression in buccal and gingival squamous cell carcinoma
Authors:Esguerra Renelson L  Jia Lin  Kaneko Tomoatsu  Sakamoto Kei  Okada Norihiko  Takagi Minoru
Affiliation:Molecular Pathology and; Diagnostic Oral Pathology, Department of Oral Restitution, and; Pulp Biology and Endodontics, Department of Restorative Sciences, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Abstract:
Centromere protein F (CENP-F) expression (localization and characteristics) in relation to tumor clinicopathological parameters was immunohistochemically examined and evaluated in 47 archival biopsy specimens of buccal and gingival squamous cell carcinomas (SCC). Centromere protein F expression was detected in 79% of the samples. An increase in the labeling index (LI) with WHO grading was obtained ( P  < 0.05). Correlations were obtained between the CENP-F LI and tumor size ( P  < 0.05). Immunoelectron microscopy showed CENP-F nuclear staining as punctate or fine dots. The present study shows that CENP-F expression and detection of a more specific cell subpopulation presents a theoretical advantage for the analysis of the precise cell cycle of G2 to M cells, compared to Ki-67.
Keywords:centromere protein F    immunoelectron microscopy    immunohistochemistry    squamous cell carcinoma
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