| 白芍总甙对豚鼠结肠平滑肌作用机制的研究 |
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| 引用本文： | 杨小军,李建军,轩原清史,魏睦新.白芍总甙对豚鼠结肠平滑肌作用机制的研究[J].中国中西医结合消化杂志,2002,10(3):151-153. |
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| 作者姓名： | 杨小军 李建军 轩原清史 魏睦新 |
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| 作者单位： | 1. 南京医科大学第一附属医院中医科,南京,210029
2. 日本岛津综合科学研究所,东京,#101-0054 |
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| 摘 要： | 目的 :探讨白芍总甙 (TGP)对离体豚鼠结肠平滑肌的作用方式及对结肠平滑肌中 P物质 (SP)和血管活性肠肽 (VIP)释放的影响。方法 :观察不同剂量 TGP及工具药对离体结肠肌收缩活性的效应及利用 SABC法检测结肠平滑肌中 SP和血管 VIP的变化。结果 :TGP使豚鼠结肠离体平滑肌收缩积分和时间显著性增加 ,且收缩效应的改变具有剂量依赖性。平滑肌中 SP的反应显著性增强。结论 :TGP可通过延长结肠收缩时间 ,增强结肠收缩幅度而调节结肠运动 ,SP是 TGP作用的递质之一。
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| 关 键 词： | 白芍总甙 P物质 血管活性肠肽 结肠平滑肌运动 |
Study on Mechanism of TGP acting on Colon Smooth Muscle of Guinea Pig |
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| YANG Xiaojun,LI Jianjun,Kyoshi nokihara,et al.Study on Mechanism of TGP acting on Colon Smooth Muscle of Guinea Pig[J].Chinese Journal of Integrated Traditional and Western Medicine on Digestion,2002,10(3):151-153. |
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| Authors: | YANG Xiaojun LI Jianjun Kyoshi nokihara |
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| Institution: | YANG Xiaojun,LI Jianjun,Kyoshi nokihara,et al Department of TCM,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029 |
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| Abstract: | Objective:To explore the effect of total glucosides of Paeony(TGP)on ex vivo colon smooth muscle of Guines pig and the release of SP and VIP in colon smooth muscle. Methods: The contraction activity of ex vivo colon traverse and longitudinal muscle strips was observed respectively at different dosage of TGP and other medicine. SP and VIP in colon of Guinea pig were tested by SABC.Results: TGP could significantly increase the contraction integral and time of the colon traverse and longitudinal muscle strips.The change of contraction was dosage independent. The number of cell with SP was increased significantly.Conclusion: TGP can regulate the motility of colon of Guinea pig by lengthening the time of contraction and reinforcing the extent of contraction.SP is one of the transmitters during the action of TGP. |
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| Keywords: | TGP(total glucosides of Paeony) SP VIP colon smooth muscle motility |
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