枳术宽中胶囊治疗功能性消化不良

目的:观察枳术宽中胶囊治疗功能性消化不良(FD)的临床疗效.方法:将80例符合病例入选标准的FD患者随机分为治疗组、对照组各40例.两组患者均嘱进食易消化食物,治疗期间禁服其他影响疗效的药物,同时给予多潘立酮,10mg/次,3次/d,口服.治疗组在对照组治疗基础上加用枳术宽中胶囊,3片/次,3次/d,口服.两组均以7d为1个疗程,治疗3个疗程后统计疗效.结果:痊愈率治疗组75.00％,对照组62.50％,两组差异显著(P＜0.05);总有效率治疗组95.00％,对照组85.00％,两组差异显著(P＜0.05).治疗后恶心呕吐、食欲下降、上腹不适、嗳气、烧心、反酸症状积分治疗组分别为(0.94±0.27),(0.95 ±0.44),(0.75 ±0.37),(0.25±0.45),(0.47 ±0.12),(0.76±0.22)分,对照组分别为(1.76±0.32),(1.51±0.55),(1.75±0.52),(1.78±0.41),(1.45±0.54),(1.45±0.51)分,两组治疗后与治疗前比明显下降(P＜0.05),治疗后治疗组改善优于对照组(P＜0.05).治疗后餐前正常慢波、餐后正常慢波、餐前餐后主功率比治疗组分别为( 43.62±18.60)％,(52.32±1.54)％,(2.87 ±2.55),对照组分别为(40.75±15.58)％,(46.32±16.64)％,(2.51±1.23),治疗后治疗组改善优于对照组(P＜0.05).结论:枳术宽中胶囊治疗FD临床疗效显著.

Clinical Investigation on Treatment of Zhizhu Kuanzhong Capsule for Functional Dyspepsia

Objective: To observe the clinical efficacy of Zhizhu Kuanzhong capsule in the treatment of functional dyspepsia (FD). Method: Eighty cases reached the standard of FD were randomly divided into treatment group, control group (n=40 each). Patients in two groups were orally given domperidone (10 mg, 3 times daily), and asked to eat easy to digest food, to avoid other drugs with potential influences. The patients in treatment group were orally treated with Zhizhu Kuanzhong capsule (3 tablets, tid). Seven days were considered as a treatment course. After 3 courses of treatment, the outcome was compared for the two groups. Result: The cure rate was 75% in treatment group, and 62.50% in control group, with significant difference (P<0.05). The total efficiency was 95% in treatment group, and 85% in control group, with significant difference (P<0.05). The side effect scores of postoperative nausea and vomiting, loss of appetite, abdominal discomfort, belching, heartburn, acid reflux symptoms in treatmentt group were (0.94 ±0.27), (0.95±0.44), (0.75+0.37) points (0.25±0.45), (0.47±0.12), (0.76±0.22) accordingly, in the control group they were (1.76±0.32), (1.51±0.55), (1.75±0.52), (1.78±0.41), (1.45±0.54), (1.45±0.51) respectively. In two groups, the scores were decreased obviously after the treatment compared with those before the treatment (P<0.05). The treatment group was better than the control group (P<0.05). After treatment, normal slow wave before meals, normal slow wave after meals and the main power ratio before and after meals in the treatment group were (43.62±18.60)%, (52.32±1.54)%, (2.87±2.55), while in the control group (40.75±15.58)%, (46.32±16.64)%, (2.51±1.23) respectively. In two groups the treatments improved the parameters significantly (P<0.05). The treatment group was better than the control group (P<0.05). Conclusion: Clinical efficacy of Zhizhu Kuanzhong capsule for the treatment of FD is satisfactory.