| P53,Ras基因突变及HPV感染与膀胱癌的关系 |
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| 引用本文： | 李一伟 黄健文. P53,Ras基因突变及HPV感染与膀胱癌的关系[J]. 中华泌尿外科杂志, 1996, 17(5): 259-262 |
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| 作者姓名： | 李一伟 黄健文 |
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| 作者单位： | 福建医学院病理教研室 |
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| 基金项目： | 国家教委优秀青年教师基金,福建省教委科研基金 |
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| 摘 要： | 应用分子生物学方法检测３２例膀胱移行上皮癌中Ｐ５３、Ｋ－ｒａｓ、ＨＰＶ基因，发现有３４．４％的膀胱癌Ｐ５３基因突变，２１．９％膀胱癌Ｋ－ｒａｓ基因突变，６．３％膀胱癌ＨＰＶ阳性。说明膀胱移行上皮癌的发生与Ｐ５３、Ｒａｓ基因突变及ＨＰＶ感染有关。膀胱癌的发生是多种基因的变化通过多种途径引起的。
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| 关 键 词： | 膀胱肿瘤，癌，基因，病毒 |
P53,Ras genes,HPV and bladder carcinoma |
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| Li Yiwei,Huang Jianwen,Wong Jingxuan.. P53,Ras genes,HPV and bladder carcinoma[J]. Chinese Journal of Urology, 1996, 17(5): 259-262 |
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| Authors: | Li Yiwei Huang Jianwen Wong Jingxuan. |
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| Abstract: | cases of transitional cell carcinoma of bladder were detected for P53,K-ras genes and HPV using molecular biologic techniques.P53 mutation was observed in 34.4%,K-ras mutation in 21.9% and HPV-positive in 6.3%.The results revealed that bladder carcinoma was related to the mutation of P53 and ras genes and to the HPV infection.It was postulated that the pathogenesis of bladder carcinoma was related to the change of various genes through different pathway. |
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| Keywords: | Bladder neoplasms Carcinoma Gene Viruses |
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