| nm23产物／NDPK表达与精原细胞瘤生物学行为 |
| |
| 引用本文： | 李光伟,温强.nm23产物／NDPK表达与精原细胞瘤生物学行为[J].中华泌尿外科杂志,1996,17(10):624-626. |
| |
| 作者姓名： | 李光伟 温强 |
| |
| 作者单位： | 沈阳医学院附属中心医院泌尿外科，沈阳医学院附属中心医院病理科，中国医科大学第一临床学院泌尿外科，沈阳军区二○二医院 |
| |
| 摘 要： | 为了解ｎｍ２３在精原细胞瘤发生、进展过程中所起的作用，应用Ｓ－Ｐ免疫组织化学方法、兔抗ＮＤＰＫ多克隆抗体对精原细胞瘤及正常睾丸组织中ｎｍ２３产物／ＮＤＰＫ的表达进行了检测。结果：３８例肿瘤和５例正常睾丸生殖上皮组织中ｎｍ２３／ＮＤＰＫ均呈阳性表达。肿瘤组织中的表达强度明显高于正常生殖上皮组织，而与其组织病理类型无关，强表达缺失与肿瘤的转移行为有关。提示ｎｍ２３／ＮＤＰＫ在精原细胞瘤发生和转移抑制过程中可能起重要作用
|
| 关 键 词： | 精原细胞瘤，基因，免疫组织化学 |
nm23 products/NDPK expression and the biological behavior of seminoma |
| |
| Li Guangwei, Wen Qiang, Wang Lizhong,et al..nm23 products/NDPK expression and the biological behavior of seminoma[J].Chinese Journal of Urology,1996,17(10):624-626. |
| |
| Authors: | Li Guangwei Wen Qiang Wang Lizhong |
| |
| Institution: | Li Guangwei, Wen Qiang, Wang Lizhong, et al. |
| |
| Abstract: | nm23/NDPK expression was studied in seminoma and normal testis tissue by S-P immunohistochemistry using rabbit anti-NDPK polyclonal antibody. Positive expression was observed in all the 31 seminoma and 5 normal testis tissues while the expression level has been significantly higher in the former. Loss of overexpression was relevant to the metastasis behavior of the tumor(P<0. 05); The results denoted that nm23/DNPK might play an important role in the carcinogenesis of seminoma and in suppessing its metastasis potential. |
| |
| Keywords: | Seminoma Genes Immunohistochemistry |
| 本文献已被 CNKI 维普 等数据库收录！ |
