国产硫普罗宁治疗抗精神病药物所致肝损害的对照研究

为探讨硫普罗宁对抗精神病药物所致肝损害等不良反应预防和治疗的有效性及安全性,采用随机对照实验方法,将适应症患者分为两组:实验组142例使用抗精神病药物的同时口服硫普罗宁400mg/d;对照组145例使用抗精神病药物的同时口服安慰剂,疗程8周。结果,两组精神疾病疗效相同,实验组肝损害发生率总计为23.94％,第4、6、8周分别为6.34％、7.10％、4.96％,恶心呕吐及白细胞降低分别为2.11％、1.41％;对照组肝损害发生率总计为53,10％,第4、6、8周分别为15.49％、17.61％、12.68％,恶心呕吐及白细胞降低分别为8.28％、6 21％,实验组均明显低于对照组(P<0.05～0.01)。提示,精神疾病患者在使用抗精神病药物治疗的同时联用硫普罗宁对抗精神病药物所致的肝损害等不良反应的发生有预防和治疗作用,且不影响抗精神病药物的疗效。

Control Studies of Tiopronin in the Treatment of Hepatic Damage Induced by Antipsychotics

To explore the efficacy and safety of tiopronin in preventing and treating hepatic damage induced by antipsychotics, indicated patients were randomly di-vidied into two groups in this control experiment; the experimental group(n=142) orally took tiopronin 400mg/d and the control group(n= 145) did placebo at the same time of taking antipsychotics. Results: The two groups had same effect; In the experimental group, the total incidence of hepatic damage was 23. 94%,in the 4th, 6th and 8th weeks the incidence were 6. 34%, 7. 10% and 4. 96% .respectively; that of the nausea and vomiting and the decrease of WBC were 2. 11% and 1. 41% ,respectively. In the control group, the total incidence was 53. 10%,in 4th, 6th and 8th weeks the incidence were 15. 49%, 17. 61% and 12. 68% .respectively; that of the nausea and vomting and the decrease of WBC were 8. 28% and 6. 21%, respectively. The rates were all lower in the experimental group than in the control group(P<0. 05 - 0. 01). Conclusion: At the same time of taking antipsychotics, combining with tiopronin has preventing and treating action on hepatic damage induced by antipsychotics,and don't affect the curative effect of antipsychotics.