超声造影评价宫颈癌放化疗效果的临床价值

目的探讨超声造影（CEUS）评价中晚期宫颈癌放化疗效果的临床价值。方法对28例中晚期宫颈癌患者放化疗前后进行CEUS检查，分析其表现及时间一强度曲线（TIC）部分参数的变化。结果28例患者放化疗前测量肿瘤大小的范围13．2～98．3mm。，浸润深度（18．9±10．5）mm，7例见阴道侵犯，1例见膀胱侵犯。放化疗后9例肿块完全消退，17例部分消退，2例无变化；浸润深度（9．7±7.8）mm，与治疗前比较具有统计学意义（P〈0．01）。3例阴道侵犯完全消退；1例膀胱侵犯未见明显变化。TIC参数在治疗后表现为显影时间（AT）、达峰时间（TTP）及增强时间（△T）延长，增强强度（EI）及单位时间强度变化（k）明显减少，与治疗前比较均有统计学意义。结论CEUS可以为中晚期宫颈癌的临床治疗效果评价提供可靠信息。

Value of Contrast-enhanced Ultrasound in Evaluting Effects of Chemotherapy and Radiotherapy on Cervical Carcinoma

Objective To explore contrast-enhanced ultrasound （ CEUS ） in evaluting effects of chemotherapy and radiotherapy on local advanced cervical carcinoma. Methods Twenty-eight cases of local advanced cervical carcinoma underwent CEUS with SonoVue before and after chemotherapy and radiotherapy.The sonographic characteristics and the perfusion quantified parameters of time-intensity curve （TIC） were analyzed. Results In the twenty-eight cases before treatment , the measurement of tumor size was 13.2 to 98.3mm2, infiltration depth was （ 18.9 ~ 10.5 ）mm, seven cases were infiltrated into vagina, one case was infiltrated into urinary bladder.Aftter treatment, nine cases showed complete remission （ CR ）, seventeen cases showed partial remission （ PR ）, two cases showed stable disease （ SD ）, infiltration depth was （ 9.7 ＋ 7.8 ） mm. Compared with the data before treatment the difference was significant （P 〈 0.01 ） , three cases with vagina infiltration showed complete regression, one case with urinary bladder infiltration had no change.Compared with the data before treatment, the arrival time （ AT ）, the time to peak （ TTP ） and the enhancal time （ A T ） was increased obviously while the enhanced intensity （ EI ） and the unit time strength changes （ k ） were lessened obviously （ the difference was significant ）. Conclusion CEUS can provide useful evidence for evaluting effects of chemotherapy and radiotherapy on local advanced cervical carcinoma