尿激酶溶栓治疗时间对急性心肌梗死患者左心室收缩功能的影响

目的探讨尿激酶溶栓治疗急性心肌梗死患者的启动时间及用药后对患者左心室收缩功能的影响。方法选择我科收治的急性心肌梗死患者60例，按照尿激酶溶栓治疗的不同启动时间（3、6、12h）分为三组各20例。于发病后第7天采用心脏超声检测患者的左心室收缩功能并进行比较。结果三组溶栓人数比较差异有统计学意义（P〈0．05）。3h溶栓组的左心室射血分数（LVEF）、左心室短轴缩短率（LVFS）、室间隔收缩幅度（LVPWae）、左心室后壁收缩幅度（IVSae）均明显高于另外两组，三组间以上指标比较有显著差异（P〈0．05）。结论急性心肌梗死患者应于发病3h内行尿激酶溶栓治疗，此时间内用药可明显改善患者的左心室收缩功能。

Effect of Urokinase Thrombolysis Start time on Left Ventricular Systolic Function in Patients with Acute Myocardial Infarction

Objective To explore the effects of urokinase thrombolysis start time on left ventricular systolic function in patients with acute myocardial infarction. Methods Selected 60 patients with acute myocardial infarction, divided them by Start time of urokinase Thrombolysis （3h,6h,12h） into 3 groups, 20 patients in each group. On 7th day after invasion, test left ventricular systolic function through cardiac ultrasonography and make comparision. Results Comparative difference of 3 groups data, There was statistically significant （P 〈 0.05 ）. LVEF of 3h group, LVFS, LVPWae, IVSae was obviously higher than other 2 groups, index above among 3 groups was different （ P 〈 0.05 ）. Conclusion Patients with acute myocardial infarction should receive treatment of urokinase thrombolysis within 3h after invasion, ventricular systolic function can be improved by medication.