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CAG预激方案联合伊马替尼治疗复发/难治性Ph+急性淋巴细胞白血病首例报道
引用本文:张翔,何广胜,吴德沛,孙爱宁,金正明,仇惠英,苗瞄,唐晓文,傅铮铮,韩悦,马骁,陈苏宁,薛胜利,赵晔,王荧,王秀丽,吴小津. CAG预激方案联合伊马替尼治疗复发/难治性Ph+急性淋巴细胞白血病首例报道[J]. 临床血液学杂志, 2008, 21(6)
作者姓名:张翔  何广胜  吴德沛  孙爱宁  金正明  仇惠英  苗瞄  唐晓文  傅铮铮  韩悦  马骁  陈苏宁  薛胜利  赵晔  王荧  王秀丽  吴小津
作者单位:苏州大学附属第一人民医院血液科江苏省血液病研究所
基金项目:江苏省青年科技人才基金,江苏省医学重点学科建设和人才战略工程项目,苏州大学校科研和教改项目,江苏省卫生厅"135工程"医学重点人才基金 
摘    要:目的:寻找有效治疗复发/难治性Ph染色体阳性急性淋巴细胞白血病(Ph ALL)的疗法。方法:以CAG预激方案联合伊马替尼诱导治疗复发/难治性Ph ALL病例1例。结果:该复发/难治Ph ALL患者经CAG方案联合伊马替尼诱导治疗后达缓解。结论:对于复发/难治性Ph ALL,CAG联合伊马替尼是一个值得尝试的方案。

关 键 词:白血病  淋巴细胞  急性  Ph染色体  CAG预激方案  伊马替尼

First case report of treating relapsed/refractory Ph+ acute lymphoblastic leukemia by CAG regimen plus imatinib
ZHANG Xiang,HE Guangsheng,WU Depei,SUN Aining,JIN Zhengming,QIU Huiying,MIAO Miao,TANG Xiaowen,FU Zhengzheng,HAN Yue,MA Xiao,CHEN Suning,XUE Shengli,ZHAO Ye,WANG Ying,WANG Xiuli,WU Xiaojin. First case report of treating relapsed/refractory Ph+ acute lymphoblastic leukemia by CAG regimen plus imatinib[J]. Journal of Clinical Hematology, 2008, 21(6)
Authors:ZHANG Xiang  HE Guangsheng  WU Depei  SUN Aining  JIN Zhengming  QIU Huiying  MIAO Miao  TANG Xiaowen  FU Zhengzheng  HAN Yue  MA Xiao  CHEN Suning  XUE Shengli  ZHAO Ye  WANG Ying  WANG Xiuli  WU Xiaojin
Abstract:Objective:To explore the effective treatment for relapsed/refractory Ph chromosome positive acute lymphoblastic leukemia(Ph ALL).Method:One relapsed/refractory Ph ALL patient was treated by CAG(low-dose cytarabine,aclarubicin hydrochloride and granulocyte colony-stimulating factor) regimen plus Imatinib.Result:The patient responded to one course CAG regimen plus Imatinib who resulted in complete remission(CR).Conclusion:The regimen consisting of CAG and Imatinib is worth exploring for relapsed/refractory Ph ALL.
Keywords:Leukemia  lymphoblastic  acute  Ph chromosome  CAG regimen  Imatinib
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