骨形成蛋白家族与牵引成骨术

牵引成骨术(DO)中新骨的形成具有胚胎骨的发生和正常骨折愈合的某些特征,骨形成蛋白家族(BMPs)在其中扮演了重要角色。本文就BMPs与DO的生物学联系、作用调节机制、外源性BMPs的应用等方面作一综述。

Bone morphogenetic proteins and distraction osteogenesis

Bone formation in distraction osteogenesis(DO) resembles aspects of both normal fracture healing and embryonic bony developments. Bone morphogenetic proteins(BMPs) play an important role in the signaling pathways that link the mechanical forces created by distraction to biological responses. The molecular signals that govern distraction-induced bone formation have not been fully elucidated. Specifically, the role of BMPs in DO remains unclear. BMPs is a differentiation factor which has been shown to induce bone formation and heal bone defects in a variety of animal models now. Although this technique has revolutionized the treatment of many bony defects and deformities, the main problem is the long period of treatment in clinical practice, which often involve significant complications and considerable social psychological problems. Long duration of the bone consolidation phase can be a primary cause. Then, there is a burning need for augmentation of bone consolidation to shorten the long procedure of DO clinically. Experimental study of effects of multiform local application of BMPs in DO are outspreading recently.