内皮素受体拮抗剂对缺血性急性肾功能衰竭早期的保护作用

①目的观察内皮素受体拮抗剂ＢＱ－１２３对缺血性急性肾功能衰竭早期是否具有保护作用。②方法采用切除右肾之大鼠的急性肾缺血／再灌注动物模型，观察ＢＱ－１２３对再灌注２ｈ后肾脏多项指标的影响。③结果与生理盐水对照组相比，ＢＱ－１２３使肾组织血流量减少较小（ｔ＝３．２０２，Ｐ＜０．０１），但可显著降低血清和肾组织之丙二醛（ｔ＝２．３７６，３．１１３；Ｐ＜０．０５，０．０１）及肾皮质中钙含量（ｔ＝２．１９８，Ｐ＜０．０５），同时增加肾组织中超氧化物岐化酶活性（ｔ＝２．５５８，Ｐ＜０．０５）和肾皮质中三磷酸腺苷合成量（ｔ＝２．２９０，Ｐ＜０．０５）。两组之组织学分级比较差异无显著性（ｔ＝１．９８９，Ｐ＞０．０５）。④结论内皮素受体拮抗剂ＢＱ－１２３对缺血性急性肾功能衰竭早期之肾脏具有一定的保护作用。

PROTECTIVE EFFECTS OF AN ENDOTHELIN RECEPTOR ANTAGONIST ON THE EARLY STAGE OF ISCHEMIC ACUTE RENAL FAILURE

Objective To observe whether an endothelin receptor antagonist BQ 123 possesses the protective effects on the early stage of ischemic acute renal failure( IARF) . Methods The acute renal ischemic/reperfusion(I/R) animal model of the right nephrectomy rats were employed to observe the effects of BQ 123 on several parameters of kidneys 120 min after reperfusion. Results Compared with the control group, BQ 123 made less reduction in left renal blood flow ( t=3.202,P <0.01), significant decrease in serum and renal malondialdehyde( t=2.376,3.113;P<0.05, 0.01) and calcium content of renal cortex( t=2.198,P <0.05), and significant increase in renal tissue superoxide dismutase( t=2. 558,P <0.05) and renal cortical adenosine triphosphate( t=2.290,p<0.05), but made no significant difference in the renal histological score( t=1.989,P >0.05). Conclusion The endothelin receptor antagonist BQ 123 does provide a certain degree of protection for kidneys from the early stage of IARF.