苯妥因钠、氯丙嗪治疗慢性精神分裂症34例双盲对照观察

选择符合ＤＳＭ－Ⅲ－Ｒ精神分裂症诊断标准，病程５年以上，同时符合王氏慢性精神分裂症标准的病人４８例调配分成四组；即单用苯妥因钠治疗组１２例（Ａ组）；苯妥因钠与氯丙嗪合用组１２例（Ｂ组）；单用氯丙嗪治疗组１２例（Ｃ组）；单用肌苷片安慰剂组１２例（Ｄ组）。双盲对照治疗８周。比ＢＰＲＳ、ＳＡＮＳ呈表评定结果表明：Ａ、Ｂ、Ｃ三组病人均有不同程度的疗效。但从两量表因子分变化看，各组疗效有所不同。Ａ组对某些阴性症状有效但对阳性症状的疗效不如Ｃ组。Ｃ组的ＢＰＲＳ分下降明显而ＳＡＮＳ分下降不明显。Ｂ组对阳性症状及阴性症状均有改善。

A double-blind ComparativeStudy of Pheytoin and Chlorpromazine inChronic Schizophrenics

sing double - blind comparative study, 48patients who met DSM- -R criteria for chronicschizopbrenia were randomly divided to fourgroups within eight weeks treatment : A ,phenytoin( N = 12) ; B , phenytoin plus Chlorpromazine ( N =12 ) ; C , chlorpromazine ( N = 12 ) ; D , Inosine asplacebo (N = 12 ). The results showed that : the-mean scores of BPRS and SANS were significantlydecreased in three groups (A. B. C) ,Group A hadmore effective on some negative symptoms but lesseffective on the posifive symptoms than Group C.Group B had improvement of the negative and pos-itive symptoms.