1 Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas;6 Department of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas;12 Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas;2 Department of Pediatrics (Section of Molecular Genetics), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands;9 Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands;7 Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands;3 Department of Pathology, Dallas VA Medical Center, Dallas, Texas;4 Rudolf Buchheim Institute of Pharmacology, Justus Liebig University, Giessen, Germany;5 Gastroenterology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel;10 Estonian Genome Center, University of Tartu, Tartu, Estonia;11 Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota;8 Institute of Physiological Chemistry, Hannover Medical School, Hannover, Germany