1 The Dr Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York;2 Robarts Clinical Trials Inc, and Robarts Research Institute, Department of Medicine, and Department of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario, Canada;3 Department of Gastroenterology, University Hospital Gasthuisberg and Katholieke Universiteit, Leuven, Belgium;4 Département d’Hépato-Gastroentérologie et Centre d’Investigations Cliniques, Centre Hospitalier Régional Universitaire de Lille, Université Lille Nord de France, Lille, France;5 Division of Gastroenterology, University of California San Diego, La Jolla, California;6 Department of Gastroenterology, University of Ottawa, Ottawa, Ontario, Canada;7 Department of Gastroenterology, Inflammatory Bowel Disease Centre of the Academic Medical Centre, Amsterdam, the Netherlands;8 Department of Gastroenterology, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel;9 Takeda Pharmaceuticals International Co, Cambridge, Massachusetts;10 Takeda Pharmaceuticals International, Inc, Deerfield, Illinois;11 Division of Gastroenterology, The University of Chicago Medical Center, Chicago, Illinois