表没食子儿茶素没食子酸酯对压力超负荷导致的大鼠心肌肥厚的预防作用

目的 探讨表没食子儿茶素没食子酸酯(Epigallocathechin-3 Gallate,EGCG)是否能够抑制压力超负荷导致的心肌肥厚.方法 心肌肥厚模型通过腹主动脉收缩术(abdominal aortic constriction,AC)实现.结果 手术后3周,HW/BW在AC组比sham组增加了34％.EGCG...

Epigailocatechin-3 gallate prevents cardiac hypertrophy induced by pressure overload in rats

Objective To investigate whether Epigallocatechin-3 gallate（EGCG）supplementation could reduce in vivo pressure overloadmediated cardiac hypertrophy.Methods Cardiac hypertrophy was induced by suprarenal transverse abdominal aortic constriction（AC） in rats.Results Three weeks after AC surgery,heart to body weight ratio increased in the AC group by 34% compared to the sham group.EGCG administration suppressed the load-induced increase in heart weight by 69%.Attenuation of cardiac hypertrophy by EGCG was associated with attenuation of the increase in myocyte cell size and fibrosis induced by aortic constriction.Despite abolition of hypertrophy by EGCG,transstenotic pressure gradients did not change.Echocardiogram revealed that increased left ventricular systolic dimensions and deteriorated systolic function were relieved by EGCG.Conclusion EGCG prevents the development of left ventricular concentric hypertrophy by pressure overload.