中性粒细胞与淋巴细胞比值与冠状动脉狭窄程度的关系

目的：研究中性粒细胞与淋巴细胞比值（NLR）与冠状动脉狭窄程度的关系，探讨NLR对冠心病患者冠状动脉病变严重程度的预测作用。方法：219例患者依据冠状动脉造影结果进行冠脉Gensini评分并根据其结果将其分为低分组（0～30分）142例和高分组（〉30分）77例，检测外周血白细胞分类计数并计算NLR，应用spss17．0软件进行统计分析。结果：①NLR在不同类型冠心病患者及冠脉正常患者之间存在差异（P〈0．05）；②以冠脉Gensini积分将患者分组后，高分组NLR与低分组间差异有统计学意义（P〈0．01），单因素及多因素Logistic回归分析显示NLR与年龄、高密度脂蛋白胆固醇均是高Gensini积分的独立危险因素；③受试者工作特征曲线（ROC曲线）显示NLR的曲线下面积为0．658（95％CI：0．583—0．733），且当NLR切值取2．385时，其诊断效率最高，敏感性为64％，特异性为63％。结论：NLR是冠心病的独立危险因素，可作为预测冠状动脉狭窄程度的指标。

Relationship between neutrophil to lymphocyte ratio and severity of coronary artery stenosis

AIM： To investigate the association between neutrophil to lymphocyte ratio （NLR） and severity of coronary artery stenosis （CAS）. METHODS ： According to the results of coronary angiography, a total of 219 patients were divided into two groups according to Gensini scores： low score group （n = 142） and high score group （n =77）. RESULTS： NLR in acute coronary syndrome （ACS） group was higher than those in stable angina pectoris （SAP） group and NT group （P 〈 0. 05 ）, and the NLR in high score group was higher than that in the low score group （ P 〈 0. 01 ）. A cut-off value of 2. 385 for NLR predicted high Gensini score, with a sensitivity and specificity of 64% and 63% , respectively. Uni- and multivariate analyses showed that high levels of NLR, age and high-density lipoprotein were independent predictors of high Gensini score. CONCLUSION： Our study suggests that the NLR is an independent predictor of coronary heart disease and can be used to predict the severity of CAS.