EFFECTS OF THE INHALATION OF ENFLURANE ON HEPATIC MICROSOMAL ENZYMATIC ACTIVITIES IN THE RAT |
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| Authors: | DA ROCHA-REIS, M. G. F. HIPOLITO-REIS, C. |
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| Affiliation: | Anesthesia Department of S João Hospital, Oporto, Physiological Chemistry Laboratory of the Oporto Faculty of Medicine and Center of Pharmacology and Chemic Bio-pathology of the Oporto University Porto, Portugal |
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| Abstract: | ![]()
We have investigated the possible hepatic microsomal enzymeinduction effect of enflurane, administered by inhalation inanaesthetic doses for periods of 1 h a day. In 15 experimentalgroups, differing from one another in anaesthetic concentration(1,2 and 3% enflurane) and in the number of days of treatment(3,7, 10,14,21 and 24) we found (1) no alteration either inthe ratio of liver to body weight or in the microsomal proteincontent; (2) no modifications in aniline hydroxylase activity;(3) a decrease in the aminopynne demethylase activity aftera number of exposures, varying with the dose. |
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