白细胞介素-1,8,10与心肌缺血-再灌注损伤

目的探究白细胞介素(IL)-1,8,10在心肌缺血-再灌注损伤(MIRI)中的作用及作用机制。方法检索国内外相关文献资料,进行分析、整理、总结。结果在MIRI的过程中,伴随着细胞因子(CK)的大量释放,其中促炎因子IL-1和IL-8可通过介导炎症反应,促进心肌细胞凋亡以及促进NO合成,直接损害心肌等机制加重MIRI。而抗炎因子IL-10则通过抑制多种促炎因子和趋化因子的表达,下调MIRI的炎症反应,从而减轻MIRI。结论在MIRI的过程中,IL-1和IL-8对心肌有致损作用,而IL-10则具心肌保护作用。

Interleukin- 1,8,10 and Myocardial Ischemia-Reperfusion Injury

Objective To explore the effect and possible mechanism of interleukin(IL)-1,8 and 10 in myocardial ischemia-reperfusion injury(MIRI).Methods To analyze,tidy up and summarize the datum by searching for internal and external pertinent materials.Results During MIRI,lots of cytokine(CK) are highly released,and inflammatory,such as, CK IL-1 and IL-8 may injure myocardium and produce of NO by promoting inflammatory response and cardiomyocytes apoptosis.On the contrary,antiinflammatory CK IL-10 may reduce MIRI by inhibiting the production of many kinds of inflammatory CK.Conclusion In the process of MIRI,IL-1 and IL-8 may cause myocardial injury,but IL-10 has myocardial protective effect.