Effects of light on aging and longevity |
| |
| Affiliation: | 1. Office of the Report on Carcinogens, Division of the National Toxicology Program, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, United States;2. Department of Structural and Cellular Biology, Laboratory of Chrono-Neuroendocrine Oncology, Tulane University School of Medicine, New Orleans, LA, United States;3. Maynooth University Department of Psychology, National University of Ireland, Maynooth, County Kildare, Ireland;4. Light and Health Program, Lighting Research Center, Rensselaer Polytechnic Institute, Troy, NY, United States;5. Department of Psychology and Center for Circadian Biology, University of California, San Diego, CA, United States;6. Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States;7. Danish Cancer Society Research Centre, Copenhagen, Denmark;8. Department of Neuroscience, Neuroscience Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, United States;9. Salk Institute for Biological Studies, La Jolla, CA, United States;10. Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, United States;11. Sleep Medicine, The University of Texas-Houston McGovern School of Medicine, Houston, TX, United States;12. School of Medicine, University of Connecticut, Farmington, CT, United States;13. Center for Sleep & Circadian Biology, Northwestern University, Evanston, IL, United States;14. Division of Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands;15. National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention, Cincinnati, OH, United States;p. Office of Health Assessment and Translation, Division of the National Toxicology Program, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, United States;q. National Center on Sleep Disorders Research, Division of Lung Diseases, National Heart, Lung, and Blood Institute (NHLBI), Bethesda, MD, United States;r. Contractor in support of the NIEHS Report on Carcinogens, Integrated Laboratory Systems (ILS), Durham, NC, United States |
| |
| Abstract: | Increasing evidence suggests an important role for light in regulation of aging and longevity. UV radiation is a mutagen that can promote aging and decrease longevity. In contrast, NIR light has shown protective effects in animal disease models. In invertebrates, visible light can shorten or extend lifespan, depending on the intensity and wavelength composition. Visible light also impacts human health, including retina function, sleep, cancer and psychiatric disorders. Possible mechanisms of visible light include: controlling circadian rhythms, inducing oxidative stress, and acting through the retina to affect neuronal circuits and systems. Changes in artificial lighting (e.g., LEDs) may have implications for human health. It will be important to further explore the mechanisms of how light affects aging and longevity, and how light affects human health. |
| |
| Keywords: | Aging Circadian rhythms Light Phototherapy Mitochondria Oxidative stress |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
