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| 维药西帕依溃结安长期给药对大鼠血液学及血生化指标的影响 | |
| 引用本文： | 卡思木江·阿西木江,木巴拉克·依明江,哈木拉提·吾甫尔. 维药西帕依溃结安长期给药对大鼠血液学及血生化指标的影响[J]. 新疆医科大学学报, 2011, 34(8) |
| 作者姓名： | 卡思木江·阿西木江 木巴拉克·依明江 哈木拉提·吾甫尔 |
| 作者单位： | 新疆医科大学,新疆,乌鲁木齐,830011 |
| 摘 要： | 目的 观察维药西帕依溃结安长期给药对大鼠血液学及血生化指标的影响,并为该药的临床安全用药提供参考依据.方法 将西帕依溃结浓缩液以高、中、低剂量灌肠给予Wistar大鼠,连续6个月,实验结束时测定西帕依溃结安高、中、低剂量组与对照组大鼠血液学和血生化指标,并进行对照分析,同时观察停药4周后的恢复情况.结果 平均血红蛋白浓度、平均红细胞体积、总胆红素及门冬氨酸氨基转移酶等指标在给药组与对照组间差异有统计学意义(P<0.05),但是均在正常值范围之内.结论 维药西帕依溃结安对大鼠血液学及血生化指标无明显影响,未发现毒性反应. |
| 关 键 词： | 西帕依溃结安 血液学指标 血生化指标 |
Long term effect of Xi-Pa-Yi Kui-Jie-An on hematology and blood biochemical indexes in rats |
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| Kasimujiang·Aximujiang,Mubalake·Yimingjiang,Hamulati·Wufuer. Long term effect of Xi-Pa-Yi Kui-Jie-An on hematology and blood biochemical indexes in rats[J]. Journal of Xinjiang Medical University, 2011, 34(8) | |
| Authors: | Kasimujiang·Aximujiang Mubalake·Yimingjiang Hamulati·Wufuer |
| Affiliation: | Kasimujiang·Aximujiang,Mubalake·Yimingjiang,Hamulati·Wufuer(Xinjiang Medical University,Urumqi 830011,China) |
| Abstract: | Objective To investigate the effects of Uygur medicine Xi-Pa-Yi Kui-Jie-An on the hematological and biochemistry indexes in rats and provide a reference for clinical drug safety.MethodsThree types of Kui-Jie-An concentrated liquid enema(high,middle,low dose) administration to Wistar rats for 6 months,at the end of the experiment,some hematology and blood biochemical indicators were measure and data were compared with the recovery(4 weeks) in rats.ResultsAlthough mean corpuscular hemoglobin concentration(MCH... |
| Keywords: | Xi-Pa-Yi Kui-Jie-An enema hematology blood biochemistry |
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