清痹汤加减改善治膝骨关节炎患者MMP-3、TIMP-1的临床观察

目的探讨清痹汤加减对膝骨关节炎的治疗效果。方法膝骨关节炎的患者192例,分为研究组和对照组,每组各96例。研究组给予口服清痹汤进行治疗;对照组给予口服双氯灭痛片进行治疗。1个月后对比两组的治疗效果、副作用,同时对患者的血液进行检查,对比两组患者血液中的MMP-3、TIMP-1的含量。结果研究组治疗效果及副作用情况较对照组佳;研究组血液中的MMP-3、TIMP-1的改变优于对照组。结论灵活运用清痹汤对膝骨关节炎具有明显的治疗效果,且毒副作用较少,能有效减少MMP-3、增加TIMP-1的含量,阻止患者病情的进一步发展。

Clinical Effect Observation of Qingbi Decoction Reduction in the Treatment of 96 Cases of Knee Osteoarthritis

Objective To explore the clinical effect of Qingbi decoction reduction in the treatment of knee osteoarthritis.Methods 192 casesof knee osteoarthritis were divided into research group and control group,each group with 96 cases.The research group was given Qingbi decoction;The control group was given oral diclofenac sodium tablets for treatment.Treatment efficacy and side effects were compared one month later,and in the same time the patient's blood was checked to compare the MMP-3,TIMP-1 content.Results The therapeutic effect and side effects with control group were better;The change of MMP-3 and TIMP-1 is better than that of the control group.Conclusions Flexible using of Qingbi decoction for knee osteoarthritis has obvious therapeutic effect and less side effects,and can effectively reduce the content of MMP-3,increase the content of TIMP-1 to prevent the further development of the patient.