Preliminary pharmacokinetic studies of propylthiouracil in humans |
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| Authors: | D. Schuppan S. Riegelman B. v. Lehmann A. Pilbrant C. Becker |
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| Affiliation: | (1) Department of Pharmacy, School of Pharmacy and School of Medicine, University of California, 94143 San Francisco, California;(2) Present address: Riker Laboratories, Saint Paul, Minnesota;(3) Present address: Institut für Pharmakologie, Berlin, Germany;(4) Present address: Research Department, Aktiebolaget KABI, Stockholm, Sweden |
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| Abstract: | ![]()
Previous analytical procedures for the analysis of propylthiouracil (PTU) in blood and urine samples are questionable on several points. Therefore, a gas-liquid chromatography method has been developed which is both more sensitive and more specific. Application of this procedure confirmed that the drug was rapidly absorbed and eliminated. The mean terminal half-life in euthyroids was found to be 63 min. One hyperthyroid subject showed a far higher plasma clearance than seen with euthyroids, which requires further study.Supported in part by Grant GM 16496 from the National Institutes of Health.This paper was submitted to a Consulting Editor who served as the Journal Editor during its review process. |
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| Keywords: | propylthiouracil pharmacokinetic disposition hyperthyroid state |
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