早期应用辛伐他汀对急性冠状动脉综合征患者近期预后的影响

目的研究在急性冠状动脉综合征(ACS)发病早期,应用强化降脂治疗能否改善患者近期预后.方法将112例住院的不稳定型心绞痛或急性心肌梗死的患者,无论血清总胆固醇水平升高与否,在入院24h内随机分为对照组(n=56)和辛伐他汀组(n=56),后者开始口服辛伐他汀治疗,发病当日和3个月后分别测定血脂,并随访3个月内所有不良反应和心血管事件.结果入选时二组一般情况及血脂水平具有可比性,与对照组比较,3个月时辛伐他汀组血清胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)均明显降低(P＜0.05),同时总心血管事件明显减少,将入选时血总胆固醇水平正常的患者进行亚组分析,辛伐他汀组治疗3个月后总心血管事件亦显著降低.结论辛伐他汀在ACS的早期应用能显著降低近期心血管事件的发生率.

EFFECTS OF EARLY LOWERING - LIPID THERAPY WITH SIMVASTATIN ON PROGNOSIS OFPATIENTS WITH ACUTE CORONARY SYNDROME

Objective To study the effects of early lowering - lipid. therapy on near future prognosis in patients with acute coronary syndrome. Methods 112 patients who were hospitalized with unstable angina pectoris or acute myocardial infarction were divided into two groups randomly: control group and Simvastatin group. The latter received lowering - lipid therapy with Simvastatin for 3 months. Blood lipid was measured before and 3 months after Simvastatin treatment. Cardiovascular events and pharmacological side effects were monitored. Results The level of cholesterol,triglyceride,LDL- C in Simvastatin group were improved significantly 3 months after treatment. Cardiovascular events in Simvastatin group were less than that in control group(P<0. 05). The same result was. observed in contrast of patients with normal blood cholesterol. Conclusion Simvastatin can decrease obviously cardiovascular events in early stage of the acute coronary syndrome.