大黄甘草汤在重症急性胰腺炎患者中的治疗观察

目的探讨大黄甘草汤对重症急性胰腺炎(SAP)的治疗效果及作用机制。方法将69例SAP患者随机分为2组:常规治疗组(CT,n=34),大黄甘草汤灌胃组(DG,n=35)。在常规治疗的基础上,DG组加用大黄甘草汤灌胃。观察两组患者的心率、呼吸、血压、肝肾功能、氧合指数(PO2/FiO2)、血氧饱和度(SaO2)、血常规、血浆电解质、葡萄糖及C-反应蛋白;并行APACHEⅡ评分及腹痛缓解时间、肛门排气时间、住院时间观察;分别于患者入院时,治疗后24h、48h,96h取血测TNF-α,IL-10水平。结果治疗后24h、48h、96h,与CT组比较,DG组在白细胞、血糖、血钙、肝肾功能指标、APACHEⅡ评分均明显改善(P0.05);TNF-α水平降低(P0.05);IL-10水平升高(P0.05);APACHEⅡ评分与TNF-α呈正相关(r=0.816,P0.01),与IL-10呈负相关(r=-0.704,P0.01),TNF-α与IL-10呈负相关(r=-0.819,P0.01);腹痛缓解时间、肛门排气时间、住院天数明显改善(P0.05);DG组在治疗后急性肺损伤、胸/腹腔积液、肠麻痹/梗阻、败血症等并发症及并发症总发生率较CT组明显改善(P0.05),其余并发症及死亡率呈下降趋势,无统计学意义(P0.05)。结论大黄甘草汤治疗SAP可明显改善患者肝肾功能及全身情况,缩短住院时间,减少并发症。

The Therapeutical Effect of Rhubarb Licorice Root Decoction of Patients with Severe Acute Pancreatitis

Objective To investigate the treatment effect of rhubarb licorice root decoction of severe acute pancreatitis and its mechanism of action.Methods 69 cases of severe acute pancreatitis were randomly divided into 2 groups:conventional treatment group(conventional treatment,CT,n=34),rhubarb licorice root decoction treatment group(DG,n=35).DG group were additionaly administered rhubarb licorice root decoction based on the conventional treatment.The patients were observed with heart rate,respiration,blood pressu...