The longitudinal chronic kidney disease study: a prospective cohort study of predialysis renal failure |
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| Authors: | Perlman Rachel L Kiser Margaret Finkelstein Fredric Eisele George Roys Erik Liu Lei Burrows-Hudson Sally Port Friedrich Messana Joseph M Bailie George Rajagopalan Sanjay Saran Rajiv |
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| Affiliation: | Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan;, Division of Nephrology, Department of Internal Medicine, University of North Carolina–Chapel Hill, Chapel Hill, North Carolina;, Yale Medical Group, Yale University, New Haven, Connecticut;, Division of Nephrology, Department of Internal Medicine, Albany Medical College, Albany, New York;, Department of Biostatistics, Kidney Epidemiology and Cost Center, School of Public Health, University of Michigan, Ann Arbor, Michigan;, Amgen, Inc., Thousand Oaks, California;, University Renal Research and Education Association, Ann Arbor, Michigan;, and Department of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan |
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| Abstract: | ![]()
Chronic kidney disease (CKD) is a significant public health problem: every year the number of Americans living with CKD and requiring renal replacement therapy increases. In addition, individuals with CKD have substantially increased morbidity and mortality compared to the general population. The Longitudinal Chronic Kidney Dialysis (LCKD) Study is a multicenter, prospective, observational study of patients with moderate to severe CKD that was designed to better describe the course of the disease and the determinants of patient outcomes. Patients with moderate to severe CKD (glomerular filtration rate [GFR] < 60 ml/min/m2) from four academic nephrology clinics were enrolled between 2000 and 2002. Special cardiac and vascular testing has recently commenced as phase II of this study. Areas that have been or are currently being studied include anemia management, health-related quality of life (HRQOL), medication use, and markers of cardiovascular disease. This article describes the LCKD Study in the context of current knowledge of CKD. |
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