埃索美拉唑、左氧氟沙星与奥硝唑联用治疗慢性胃炎效果

目的观察埃索美拉唑、左氧氟沙星与奥硝唑联用治疗幽门螺杆菌阳性慢性胃炎病人的效果及安全性。方法选取97例幽门螺杆菌阳性慢性胃炎病人，随机分为治疗组50例与对照组47例。治疗组采用埃索美拉唑、左氧氟沙星与奥硝唑治疗；对照组采用埃索美拉唑、克拉霉素、阿莫西林治疗，均治疗7d，疗程结束4～6周后行^13C-尿素呼气试验检查。结果治疗组和对照组的幽门螺杆菌根治率分别为82．00％和63．83％，两组比较差异有显著性（χ^2=4．08，P〈0．05）。结论埃索美拉唑、左氧氟沙星与奥硝唑联用治疗幽门螺杆菌阳性慢性胃炎病人效果可靠，安全性好。

TRIPLE THERAPY OF ESOMEPRAZOLE, LEVOFLOXACIN AND ORNIDAZOLE FOR CHRONIC GASTRITIS

Objective To assess the efficacy and safety of combined esomeprazole, levofloxacin and ornidazole in the treatment of chronic gastritis （CG） with positive Helieobacter pylori （Hp）. Methods This study consisted of 97 patients with positive-Hp CG, who were randomized to two groups： 50 in treatment group, and 47 in control group. To those in the treatment group, esomeprazole, levofloxacin and ornidazole were offered; to those in the control, esomeprazole, clarithromydn and amoxicil- lin administered, lasting for 7 days in both groups. ^13C-urea breath test was done 4--6 weeks after completion of therapy. Results The eradication rates of Hp in the treatment group and the control group were 82.00% and 63.83%, respectively, with significant difference between the two groups （χ^2 = 4. 08, P〈0.05）. Conclusion The combination of esomeprazole, levofloxacin and ornidazole is effective and safe for positive-Hp chronic gastritis.