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Influenza A (H1N1) virus induced long-term remission in a refractory acute myeloid leukaemia |
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| Authors: | Liangshun You Yi Liu Nianci Chen Li Zhu Gaixiang Xu Zuopo Lv Yile Zhou Chenying Li Hongyan Tong Jie Jin Haitao Meng |
| Affiliation: | 1. Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China;2. Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China Zhejiang Province Key Laboratory of Hematopoietic Malignancy, Zhejiang University, Hangzhou, Zhejiang, P.R. China Zhejiang Provincial Clinical Research Center for Hematological Disorders, Hangzhou, Zhejiang, P.R. China |
| Abstract: | There have been reports of haematological cancer patients achieving spontaneous remission after being infected with the influenza A or SARS-COV-2 virus. Here, we present the first case of long-term complete remission (CR) induced by influenza A (IAV, H1N1 subtype) in a refractory AML patient and have functionally validated this finding in two different animal disease models. We observed a significant increase in the proportion of helper T cells in the patient after IAV infection. The levels of cytokines, including IL-2, IL-4, IL-6, IL-10, IL-17A, IFN-γ and TNF-α, were higher in IAV-infected patients compared with control groups. These findings indicate that the anti-tumour effects induced by IAV are closely related to the modification of the immune response. Our study provides new evidence of the anti-tumour effects of IAV from a clinical practice perspective. |
| Keywords: | acute myeloid leukaemia (AML) immunity influenza A virus |